How to spot a pharmacy and the green cross
Look for the green cross (croce verde) — neon, often pulsing — on a sign over the door. The word 'FARMACIA' is always written clearly. There are roughly 1,000 pharmacies in Rome, density highest in the historic center and around Termini. A second category called 'parafarmacia' sells some OTC medicines but cannot dispense prescription drugs and has fewer regulated products — for actual medicine go to a farmacia (full pharmacy) not a parafarmacia.
Opening hours and the 'farmacie di turno' system
Standard hours: 08:30–13:00 and 16:00–19:30, closed Sunday. Many central pharmacies now stay open continuously 09:00–20:00. By law, at least some pharmacies in every district must stay open 24/7 on a rotating shift — these are called 'farmacie di turno' (on-duty pharmacies). When a pharmacy is closed, a sign on the door (and the website farmacistipercaso.it or comune.roma.it/pharmacy-on-duty) lists the nearest on-duty ones. After 22:00 some on-duty pharmacies charge a small night supplement (3–5€).
24-hour pharmacies in central Rome (always open)
These don't rotate — they're open 24/7, 365 days a year: Farmacia Internazionale (Piazza Barberini, 49 — opposite Hotel Bernini), Farmacia della Stazione (Piazza dei Cinquecento 49–51, inside Termini station), Farmacia Piram (Via Nazionale 228, near Termini), Farmacia del Vaticano (Via di Porta Angelica, near St Peter's). All have at least one staff member who speaks English. Inside Fiumicino airport: 24h pharmacy in Terminal 3 arrivals.
What you can buy without a prescription (OTC)
More than you'd expect. Pain relief: paracetamol (Tachipirina), ibuprofen (Nurofen, Brufen up to 400mg), aspirin (Aspirina). Allergy: cetirizine (Zirtec), loratadine (Clarityn) tablets and nasal sprays. Cold/flu: throat lozenges, decongestants, vitamin C, antiseptic mouthwash. Stomach: antacids, anti-diarrheal (Imodium), oral rehydration salts. Skin: hydrocortisone 0.5% cream, antiseptic creams, sunburn lotion, insect bite gel. Women's health: pregnancy tests, emergency contraception (Norlevo, EllaOne — both available without prescription to anyone over 18, around 15–35€). Eye drops, contact lens solution, bandages, blister plasters.
What requires a prescription (and how to handle it)
Antibiotics (any kind), strong painkillers (codeine, tramadol), sleeping pills, ADHD medication, most psychotropic drugs, blood pressure and cholesterol medications, asthma inhalers — all require an Italian prescription. If you take regular medication, bring a photo of your home prescription and the original packaging; many pharmacists will dispense a small supply for ongoing chronic medication if you can show you're a regular user. For acute issues (e.g. severe sore throat suggesting strep), a private GP visit costs 80–120€ and they will write a prescription on the spot.
Prices, payment and the receipt for insurance
Prices are regulated by the state — they are identical in every pharmacy in Italy (within the same brand). A box of Tachipirina 500mg (paracetamol) is around 5–6€, ibuprofen 4–8€, cough syrup 8–14€, antibiotic course (if you have a prescription) 8–25€. Cards are accepted everywhere. Always ask for a 'scontrino fiscale' — the receipt you'll need if your travel insurance reimburses pharmacy costs. For higher-value purchases ask for a 'fattura' (invoice) with your name.
Common tourist scenarios — what to ask for
Sore throat: 'Mi serve qualcosa per il mal di gola' → they'll suggest Strepsils or Tantum Verde spray (no prescription). Upset stomach from food: 'Ho mal di pancia / diarrea, mi consiglia qualcosa?' → Imodium + Enterogermina probiotic. Sunburn: 'Sole, scottatura' → after-sun gel with aloe + hydrocortisone cream. Mosquito bites: 'Punture di zanzara' → Fenistil gel. Period pain: 'Dolori mestruali' → ibuprofen 400mg + Buscofen. Hangover headache: 'Mal di testa' → Brufen 400 + water + electrolytes. Plan B/morning-after pill: 'EllaOne o Norlevo, senza ricetta' (over 18, photo ID may be requested). Sleep aid for jet lag: only herbal options OTC (Valeriana, melatonin).
Emergencies and out-of-hours numbers
Real medical emergency: dial 112 (European emergency, English-speaking dispatcher) or 118 (medical only). Tourist medical assistance (English-speaking GP visit at your hotel within 60 min): Doctors in Italy (+39 06 808 0995, 200€/visit), Salvator Mundi (+39 06 588 961). Free public hospital ER: Policlinico Umberto I (Viale del Policlinico, near Termini), San Camillo (Trastevere), Fatebenefratelli (Tiber Island — for emergencies in the historic center). Bring passport and travel insurance card. ER triage is free; complex care is billed afterwards to your insurance or out of pocket.